Two-dimensional 1H NOESY data are routinely used to assign specific stereo-isomers based on the proton nuclear Overhauser effects (NOE's) which are strongly correlated to inter-proton distances through space. For example, NOE's may be observed for cis- protons across a double bond but not observed for trans- protons. The same technique can be used with 19F in fluorinated compounds to gauge the inter-fluorine distance and assign stereochemistry. The figure below shows the 19F NOESY spectrum of a fluorine containing cobalt complex.
From the 1D-19F NMR spectrum, it is not clear which fluorine atoms are on the same or opposite sides of the four membered cobalt containing ring. The 2D-19F NOESY spectrum, on the other hand, shows strong NOE cross peaks between fluorine C and both A and E indicating that C, A and E are on the same side of the ring. There are also strong cross peaks between fluorine D, and both B and F indicating that D, B anf F are on the same side of the ring.