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Tuesday, April 29, 2008

1H - 11B HMQC

HMQC and HSQC experiments are very commonly applied to 1H - 13C and 1H - 15N. These techniques can also be applied to other isotopes. The figure below shows the 1H - 11B HMQC spectrum or ortho-carborane. The top and side traces are separately acquired 1H [11B] and 11B [1H] spectra, respectively. These data, combined with the 11B COSY data, allow the complete assignment of the 1H [11B] spectrum.
Thank you to Dominique Duguay for providing the sample of ortho-carborane.

5 comments:

tantalum said...

It's a powerful technique for the 1J proton-boron couplings. We used it quite a bit in Warren Piers' group to show direct boron-proton interactions.

Kevin Cook

Glenn Facey said...

March 2, 2009

The original figure in this post had proton positions 2 and 5 and boron positions A and D assigned incorrectly. The figure was changed to reflect the correct assignments. Thank you to Guangyu Li for bringing this to my attention and pointing out the following reference:

Siedle, Bodner, Garber, Deer and Todd, Inorganic Chemistry 13(10) p. 2321 (1974).

Glenn

Anonymous said...

Nice experiment. I am wondering which gradient ratio you are using to get such results
Thanks in advance

Glenn Facey said...

Anonymous,
The gradients were calculated using the Bruker au program "gradratio". This data was collected with hmqcgpqf pulse sequence with GPZ1=60, GPZ2=20 and GPZ3=65.67.
Glenn

Patrick said...

Thanks a lot for your quick answer