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Monday, November 26, 2007

HMQC Responses in HMBC Data

Despite the built in low pass J filters written into the HMBC pulse sequences, the much larger one-bond 1H - 13C coupling responses are not fully suppressed. These one-bond HMQC responses show up as a pair of responses in the acquisition domain separated by the one-bond 1H - 13C coupling. The responses are doubled since 13C decoupling is not typically used in HMBC sequences. An example of these artifacts is shown below.

2 comments:

Anonymous said...

How to avoid such artefacts?

Glenn Facey said...

Anonymous,

To the best of my knowledge, there is no way to fully suppress these on-bond correlations aside from using various "low pass filters" written into the pulse programs.

Glenn